Publications and Presentations
ACE-011 / Activin
Relevant Presentations:
RAP-011 (a Soluble Activin Receptor Type IIa) Increases Bone Mineral Density in Combination with Prior Antiresorptive Therapy (ASBMR 2007)
A Soluble Activin Type II Receptor Prevents Myeloma Bone Disease (XIth International Myeloma Workshop 2007)
The Use of a Soluble Activin Receptor Type IIA as a Novel Anabolic Agent for Treatment of Bone Loss (ECCEO 2007)
Comparison of Skeletal Effects of a Soluble Activin Receptor Type IIA (ActRIIa), PTH and Zolendronate in Ovariectomized Mice (ECCEO 2007)
Other Related Publications:
A Soluble Activin type IIA Receptor Induces Bone Formation and Improves Skeletal Integrity, R. Scott Pearsall, et al., PNAS, 105: 7087-7087, 2008
Mechanisms of Anabolic Therapies for Osteoporosis, E. Canalis, et al., The New England Journal of Medicine. 357:905-916, 2007
Inhibitory effects of activin-a on osteoblast differentiation during cultures of fetal rat calvarial cells, T. Ikenoue et. al., J. Cell. Biochem. 75:206-214, 1999
Activin A Is an Essential Cofactor for Osteoclast Induction, K. Fuller et. al., BBRC. 268:2–7, 2000
ACE-03X / Myostatin
Relevant Presentations:
Treatment with a Soluble Activin Receptor IIb Attenuates Glucocorticoid-induced Muscle Loss (WMS 2007)
Treatment with a Soluble Activin Receptor IIb Causes Increased Muscle Mass and Strength in mdx Mice (Gordon Research Conference on Myogenesis 2007)
Other Related Publications:
Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein. Q. Li, et al. Mol. Hum. Reproduc. Aug 18, 2007
A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs, Mosher DS et al. PLoS Genet 3(5): e79, 2007
Regulation of myostatin activity and muscle growth, S-J Lee et. al., PNAS, 98:9306-9311, 2001
Regulation of muscle growth by multiple ligands signaling through activin type II receptors, S-J Lee et. al., PNAS 102:18117-18122, 2005
Muscular atrophy of caveolin-3–deficient mice is rescued by myostatin inhibition, Y. Ohsawa et. al., J. Clin. Invest. 116:2924–2934, 2006
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